The human Myt1 kinase preferentially phosphorylates Cdc2 on threonine 14 and localizes to the endoplasmic reticulum and Golgi complex.

作者: F Liu , J J Stanton , Z Wu , H Piwnica-Worms

DOI: 10.1128/MCB.17.2.571

关键词:

摘要: … The activity of Cdc2 is regulated not only by its association with B-type cyclins but also by reversible phosphorylation (for a review, see reference 1). Throughout the early phases of the …

参考文章(53)
C.H. McGowan, P. Russell, Cell cycle regulation of human WEE1. The EMBO Journal. ,vol. 14, pp. 2166- 2175 ,(1995) , 10.1002/J.1460-2075.1995.TB07210.X
L. Meijer, L. Azzi, J.Y. Wang, Cyclin B targets p34cdc2 for tyrosine phosphorylation. The EMBO Journal. ,vol. 10, pp. 1545- 1554 ,(1991) , 10.1002/J.1460-2075.1991.TB07674.X
J.V. Frangioni, A. Oda, M. Smith, E.W. Salzman, B.G. Neel, Calpain-catalyzed cleavage and subcellular relocation of protein phosphotyrosine phosphatase 1B (PTP-1B) in human platelets. The EMBO Journal. ,vol. 12, pp. 4843- 4856 ,(1993) , 10.1002/J.1460-2075.1993.TB06174.X
N. Watanabe, M. Broome, T. Hunter, Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle. The EMBO Journal. ,vol. 14, pp. 1878- 1891 ,(1995) , 10.1002/J.1460-2075.1995.TB07180.X
Y. Gu, J. Rosenblatt, D.O. Morgan, Cell cycle regulation of CDK2 activity by phosphorylation of Thr160 and Tyr15. The EMBO Journal. ,vol. 11, pp. 3995- 4005 ,(1992) , 10.1002/J.1460-2075.1992.TB05493.X
C. Norbury, J. Blow, P. Nurse, Regulatory phosphorylation of the p34cdc2 protein kinase in vertebrates. The EMBO Journal. ,vol. 10, pp. 3321- 3329 ,(1991) , 10.1002/J.1460-2075.1991.TB04896.X