Liposome-encapsulated ursolic acid increases ceramides and collagen in human skin cells.
作者： Dawn M. Both , Karina Goodtzova , Daniel B. Yarosh , David A. Brown
DOI: 10.1007/S00403-001-0272-0
关键词:
摘要: Skin wrinkling and xerosis associated with aging result from decreases in dermal collagen stratum corneum ceramide content. This study demonstrated that ursolic acid incorporated into liposomes (URA liposomes) increases both the content of cultured normal human epidermal keratinocytes (NHEK), fibroblasts. In addition, URA increased skin subjects, hydroxy ceramides occurring after only 3 days treatment. Both retinoic decreased markers keratinocyte differentiation (keratin 1, keratin 10 involucrin) NHEK. Thus, have effects on fibroblast synthesis similar to those retinoids. However, this showed increase NHEK, contrast previously shown be caused by potential used alone or combination other agents restore maintain
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