Advances on Tumor-Targeting Delivery of Cytotoxic Proteins.
作者： Akmal M. Asrorov , Zeyun Gu , Kyoung Ah Min , Meong Cheol Shin , Yongzhuo Huang
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摘要: Great attention has been paid to cytotoxic proteins (e.g., ribosome-inactivating proteins, RIPs) possessing high anticancer activities; unlike small drugs, can effectively retain inside the cells and avoid drug efflux mediated by multidrug resistance transporters due large-size effect. However, clinical translation of these is severely limited because various biobarriers that hamper their effective delivery tumor cells. Hence, in order overcome barriers, many smart systems (DDS) have developed. In this review, we will introduce two representative type I RIPs, trichosanthin (TCS) gelonin (Gel), overview major for protein-based cancer therapy. Finally, outline advances on development DDS applications treatment.
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