The impact of substance use at psychosis onset on First Episode Psychosis course: Results from a 1 year follow-up study in Bologna

摘要: Abstract Objectives Substance abuse is a well established risk factor for First-Episode Psychosis (FEP), but its influence on FEP course less clear. Starting from our baseline observation that substance users were younger than non-users at the psychosis onset, we hypothesized use could be an independent worse clinical course. Methods An incidence cohort of patients with collected in 8 year period (2002–2009) Bologna West Community Mental Health Centers (CMHCs) was assessed and 12 month follow-up. Drop-out, hospitalizations service utilization used as outcomes. Results Most still contact CMHC follow up. had significantly higher rate during follow-up after adjusting age, gender other potential confounders (OR 5.84, 95% CI 2.44–13.97, p ≤ 0.001). Conclusions This study adds to previous evidence showing effect The identification “potentially modifiable” environmental predictor illness such onset allows us envisage possibility ameliorating by managing this factor.