Precise redox-sensitive cleavage sites for improved bioactivity of siRNA lipopolyplexes

作者: Philipp Michael Klein , Sören Reinhard , Dian-Jang Lee , Katharina Müller , Daniela Ponader

DOI: 10.1039/C6NR05767E

关键词:

摘要: … added dropwise to the reaction mixture at 0 C and stirred over-night. The reaction mixture was … g of bromophenol blue) was added. Electrophoresis was performed at 100 V for 40 min. …

参考文章(37)
Sebastian Wieczorek, Sara Vigne, Tiziana Masini, Daniela Ponader, Laura Hartmann, Anna K. H. Hirsch, Hans G. Börner, Combinatorial Screening for Specific Drug Solubilizers with Switchable Release Profiles Macromolecular Bioscience. ,vol. 15, pp. 82- 89 ,(2015) , 10.1002/MABI.201400443
Qixin Leng, Szu‐Ting Chou, Puthupparampil V. Scaria, Martin C. Woodle, A. James Mixson, Increased tumor distribution and expression of histidine‐rich plasmid polyplexes Journal of Gene Medicine. ,vol. 16, pp. 317- 328 ,(2014) , 10.1002/JGM.2807
Mathieu Mével, Thomas Haudebourg, Thibault Colombani, Pauline Peuziat, Laurence Dallet, Benoît Chatin, Olivier Lambert, Mathieu Berchel, Tristan Montier, Paul-Alain Jaffrès, Pierre Lehn, Bruno Pitard, Important role of phosphoramido linkage in imidazole-based dioleyl helper lipids for liposome stability and primary cell transfection The Journal of Gene Medicine. ,vol. 18, pp. 3- 15 ,(2016) , 10.1002/JGM.2869
Ji Hoon Jeong, Lane V. Christensen, James W. Yockman, Zhiyuan Zhong, Johan F.J. Engbersen, Won Jong Kim, Jan Feijen, Sung Wan Kim, Reducible poly(amido ethylenimine) directed to enhance RNA interference Biomaterials. ,vol. 28, pp. 1912- 1917 ,(2007) , 10.1016/J.BIOMATERIALS.2006.12.019
David Schaffert, Naresh Badgujar, Ernst Wagner, Novel Fmoc-polyamino acids for solid-phase synthesis of defined polyamidoamines. Organic Letters. ,vol. 13, pp. 1586- 1589 ,(2011) , 10.1021/OL200381Z
Laura Hartmann, Eberhard Krause, Markus Antonietti, Hans G. Börner, Solid-phase supported polymer synthesis of sequence-defined, multifunctional poly(amidoamines) Biomacromolecules. ,vol. 7, pp. 1239- 1244 ,(2006) , 10.1021/BM050884K
Thomas Fröhlich, Daniel Edinger, Raphaela Kläger, Christina Troiber, Edith Salcher, Naresh Badgujar, Irene Martin, David Schaffert, Arzu Cengizeroglu, Philipp Hadwiger, Hans-Peter Vornlocher, Ernst Wagner, Structure–activity relationships of siRNA carriers based on sequence-defined oligo (ethane amino) amides Journal of Controlled Release. ,vol. 160, pp. 532- 541 ,(2012) , 10.1016/J.JCONREL.2012.03.018
Jin-Biao Ma, Keqiong Ye, Dinshaw J. Patel, Structural basis for overhang-specific small interfering RNA recognition by the PAZ domain. Nature. ,vol. 429, pp. 318- 322 ,(2004) , 10.1038/NATURE02519
Rumiana Koynova, Boris Tenchov, Li Wang, Robert C. MacDonald, Hydrophobic moiety of cationic lipids strongly modulates their transfection activity. Molecular Pharmaceutics. ,vol. 6, pp. 951- 958 ,(2009) , 10.1021/MP8002573
Christina Troiber, Daniel Edinger, Petra Kos, Laura Schreiner, Raphaela Kläger, Annika Herrmann, Ernst Wagner, Stabilizing effect of tyrosine trimers on pDNA and siRNA polyplexes. Biomaterials. ,vol. 34, pp. 1624- 1633 ,(2013) , 10.1016/J.BIOMATERIALS.2012.11.021