Combinatorial Screening for Specific Drug Solubilizers with Switchable Release Profiles
作者： Sebastian Wieczorek , Sara Vigne , Tiziana Masini , Daniela Ponader , Laura Hartmann
关键词: Combinatorial chemistry 、 Peptide 、 Drug delivery 、 Linker 、 Bioconjugation 、 Peptide binding 、 Photosensitizer 、 Chemistry 、 Small molecule 、 Moiety
摘要: Polymer-block-peptide conjugates are tailored to render hydrophobic small molecule drugs water soluble. The combinatorial strategy selects for bioconjugates that exhibit sequence-specific solubilization and switchable release profiles of the cargo through incorporation a disulfide linker moiety into peptide-library design. While study focused on photosensitizer m-THPC reductive carrier cleavage, approach is generic might be expanded toward broad range poorly soluble small-molecule other selective cleavage mechanisms disassemble peptide binding domain bioconjugate-based solubilizer.
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