The liver X receptor agonist T0901317 acts as androgen receptor antagonist in human prostate cancer cells
作者： Chih-pin Chuu , Rou-Yu Chen , Richard A. Hiipakka , John M. Kokontis , Karen V. Warner
DOI: 10.1016/J.BBRC.2007.03.116
关键词:
摘要: T0901317 is a potent non-steroidal synthetic liver X receptor (LXR) agonist. blocked androgenic stimulation of the proliferation androgen-dependent LNCaP 104-S cells and suppression androgen-independent 104-R2 cells, inhibited transcriptional activation an reporter gene by androgen, suppressed protein expression prostate specific antigen (PSA), target androgen (AR) without affecting AR. also binding radiolabeled to AR, but inhibition was much weaker compared effect antiandrogens, bicalutamide hydroxyflutamide. The LXR agonist T0901317, therefore, acts as antiandrogen in human cancer cells.
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