Mechanism for signaling initiation and termination of B lymphocyte proliferation induced by anti-immunoglobulin

摘要: Several lines of evidence were explored which taken together indicate that both the initiation and termination signal for activation rabbit lymphocytes to synthesize DNA in response anti-rabbit immunoglobulin occurs at an receptor on surface membrane B cells. Thus, premature removal by simply washing cells 31st hour a 48-h incubation period caused 60% decrease induction synthesis. The addition compete with cell combining sites yielded markedly diminished activation. Addition even during latter part pulse label [3H]-thymidine was sufficient result reduced Finally, insoluble same nominal concentration as soluble also effective inducing However, it is noteworthy under conditions used not possible derive component from stimulated These data have been interpreted need continuous presence stimulate process dependent upon internalization immunoglobulin.