Endothelium-derived endothelin-1

摘要: One year after the revelation by Dr. Furchgott in 1980 that endothelium was obligatory for acetylcholine to relax isolated arteries, it clearly shown could also promote contraction. In 1988, Yanagisawa's group identified endothelin-1 (ET-1) as first endothelium-derived contracting factor. The circulating levels of this short (21-amino acid) peptide were quickly determined humans, and reported that, most cardiovascular diseases, ET-1 increased, then tagged “a bad guy.” discovery two receptor subtypes 1990, ETA ETB, permitted optimization dual antagonist 1993 Clozel's team, who entered clinical development with bosentan, which offered patients pulmonary arterial hypertension 2001. opened a Pandora's box one actors. brief review, we will discuss physiological pathophysiological role focusing on regulation vascular tone, much possible humans. coronary bed be used running example review because is susceptible endothelial dysfunction, but references cerebral renal circulation made. Many complications associated aging risk factors are initially attributable, at least part, particularly dysregulation function an imbalance close interdependence nitric oxide ET-1.