How can the overtreatment rate of "see and treat" approach be reduced in women with high-grade squamous intraepithelial lesion on cervical cytology?

摘要: The aim of this study was to determine the incidence and predictors overtreatment in “see treat” approach using loop electrosurgical excision procedure (LEEP) women with high-grade squamous intraepithelial lesion (HSIL) on cervical cytology. considered when LEEP specimens contained no pathology. Between January 2001 April 2006, 446 HSIL Pap smear underwent colposcopy followed by at Chiang Mai University Hospital. Mean age these patients 45.6 years a range 25-78 years. One hundred twenty-one (27.1%) were menopausal. Unsatisfactory observed 357 (80.0%) women. Of women, histologically-confirmed HSIL, invasive cancer, low-grade lesions, adenocarcinoma situ detected 330 (74.0%), 76 (17.0%), 9 (2.0%), 5 (1.1%), respectively. rate noted 26 or 5.8% (95% confidence interval [CI] = 3.8 8.4) By multivariate analysis, postmenopausal status only significant independent predictor an adjusted odds ratio 2.89 CI 1.30 6.43, P 0.009). When excluded from reduced 4.0%. In conclusion, appears be appropriate strategy managing could such policy is limited for premenopausal