摘要: La regulacion de la transcripcion los genes eucariotas es un proceso complejo que implica muchas proteinas diferentes, algunas las cuales se unen a motivos ADN especificos encuentran localizados en region promotora genes. Se espera necesidad mantener interacciones especificas entre factores y implicadas el ARN polimerasa II imponga limitaciones posicion relativa espaciado interaccion con ADN. El trabajo presentado esta tesis incluye desarrollo nuevo metodo para identificacion presentan una localizacion preferencial secuencias implementacion aplicacion web publica llamada PEAKS. Hemos investigado si naturaleza mayoria comunes depende del rango expresion gen. encontrado diferencias sirven ilustrar hecho senales clave genica pueden estar presentes proximal promotor mamiferos. Tambien aplicamos otros metodos (TFs) involucrados co-regulacion grupo Evidencia experimental sitios union (TFBS) apoyan relevancia biologica nuestros resultados.
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