The power of identity-by-state methods for linkage analysis.
作者： J A Williamson , D T Bishop
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摘要: The affected-sib-pair method has been widely utilized for mapping. This methodology is aimed at mapping complex traits which have observed to be familial but Mendelian segregation, even after allowing partial penetrance, not apparent. Indications of linkage are based on the observation nonrandom segregation a marker locus in two affected siblings. We extend this more distant genetic relationships and examine power identity-by-state methods when information only available pairs relatives. depends polymorphism marker, probability identity by descent trait locus, recombination fraction between loci.
cabdirect.org参考文章(11)
N Risch, Linkage strategies for genetically complex traits. I. Multilocus models. American Journal of Human Genetics. ,vol. 46, pp. 222- 228 ,(1990)
G Thomson, Determining the mode of inheritance of RFLP-associated diseases using the affected sib-pair method. American Journal of Human Genetics. ,vol. 39, pp. 207- 221 ,(1986)
D E Weeks, K Lange, The affected-pedigree-member method of linkage analysis. American Journal of Human Genetics. ,vol. 42, pp. 315- 326 ,(1988)
Susan E. Hodge, Some epistatic two-locus models of disease. I. Relative risks and identity-by-descent distributions in affected sib pairs. American Journal of Human Genetics. ,vol. 33, pp. 381- 395 ,(1981)
D Botstein, R W Davis, R L White, M Skolnick, Construction of a genetic linkage map in man using restriction fragment length polymorphisms. American Journal of Human Genetics. ,vol. 32, pp. 314- 331 ,(1980)
J. K. Haseman, R. C. Elston, The investigation of linkage between a quantitative trait and a marker locus Behavior Genetics. ,vol. 2, pp. 3- 19 ,(1972) , 10.1007/BF01066731
Kenneth Lange, Relative-to-relative transition probabilities for two linked genes Theoretical Population Biology. ,vol. 6, pp. 92- 107 ,(1974) , 10.1016/0040-5809(74)90033-1
M. A. CAMPBELL, R. C. ELSTON, Relatives of probands: models for preliminary genetic analysis. Annals of Human Genetics. ,vol. 35, pp. 225- 236 ,(1971) , 10.1111/J.1469-1809.1956.TB01395.X
N. E. Day, M. J. Simons, Disease susceptibility genes--their identification by multiple case family studies. Tissue Antigens. ,vol. 8, pp. 109- 119 ,(2008) , 10.1111/J.1399-0039.1976.TB00574.X
William C. Blackwelder, Robert C. Elston, D. C. Rao, A comparison of sib-pair linkage tests for disease susceptibility loci Genetic Epidemiology. ,vol. 2, pp. 85- 97 ,(1985) , 10.1002/GEPI.1370020109