Association of a BACE1 Gene Polymorphism with Parkinson's Disease in a Norwegian Population.
作者： Johannes Lange , Kristin Aaser Lunde , Camilla Sletten , Simon Geir Møller , Ole-Bjørn Tysnes
DOI: 10.1155/2015/973298
关键词:
摘要: Background. Parkinson's disease (PD) and Alzheimer's (AD) share pathological features, including amyloid-beta pathology. Amyloid-beta peptide is generated by sequential proteolysis of amyloid precursor protein (APP), genetic variations in the processing pathway genes have been found to increase risk AD; however, contribution PD unknown. Methods. The aim this study was investigate whether candidate polymorphisms five (ADAM10, BACE1, BACE2, PSEN2, CLU) involved APP affect a population-based cohort patients with incident control subjects from Norwegian ParkWest study. Results. We an association rs638405 BACE1 increased PD, thus providing novel link, at level, between pathology PD.
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