Self-rated psychiatric symptoms in patients operated on because of primary hyperparathyroidism and in patients with long-standing mild hypercalcemia

摘要: Self-rated psychiatric symptoms were investigated in 30 patients referred for surgery because of primary hyperparathyroidism (HPT) (serum calcium, 2.87 +/- 0.21 mmol/L) 38 subjects detected a health screening, with 15 years mild hypercalcemia and probable HPT 2.66 0.09 mmol/L), normocalcemic control subjects. The symptomatology was evaluated by use the Hopkins Symptom Checklist (HSCL-56), self-rating symptom scale. verified had highest mean HSCL score, 89.1 20.1 before surgery, compared 76.6 17.0 (p less than 0.01) survey hypercalcemic 73.8 16.0 0.001) controls. factors anxiety, depression, cognitive most pronounced also increased among mildly persons survey, Somatic such as headache, back pain, chest weakness equally common controls, measurements isometric muscle strength knee extension did not demonstrate reduction patients. Follow-up 1 year after parathyroid revealed marked improvement mental (HSCL score 73.2 13.7, p 0.001). In patients, neither nor influenced 6 months oral vitamin D therapy (alphacalcidol). results that are experienced frequently minimum to moderate increases serum calcium level these disturbances reversed surgery.