Human papillomavirus: An unlikely etiologic factor in sinonasal inverted papilloma.
作者： Sepideh Mohajeri , Chi Lai , Bibianna Purgina , Dakheelallah Almutairi , Tabassom Baghai
DOI: 10.1002/LARY.27207
关键词:
摘要: OBJECTIVES/HYPOTHESIS Tenuous evidence has supported the hypothesis that sinonasal inverted papilloma (SNIP) arise from human papillomavirus (HPV) infection. To clarify role of HPV in SNIP, all known sub-types were evaluated by employing a robust polymerase chain reaction-based method wide variety SNIPs single institution. STUDY DESIGN Retrospective surgical specimen tumor sample analysis. METHODS positivity among SNIP samples and those with squamous cell carcinoma (SCC) compared. Immunohistochemistry was used to quantify p16 (over)expression tumors as surrogate marker for HPV. RESULTS detected 10/76 (13%) specimens. Identified subtypes included nononcogenic 6 11 (6/76, 8%) oncogenic 16, 18, 45, 56 (4/76, 5%). There no SCC samples. Only 4/10 (40%) HPV + samples had > 75% staining. CONCLUSION is not an etiological driver development or progression SCC. The biomarker sensitive indicator SNIP. LEVEL OF EVIDENCE NA Laryngoscope, 2443-2447, 2018.
sci-hub.se 参考文章(23)
Adam Scheel, Giant C. Lin, Jonathan B. McHugh, Christine M. Komarck, Heather M. Walline, Mark E. Prince, Mark A. Zacharek, Thomas E. Carey, Human papillomavirus infection and biomarkers in sinonasal inverted papillomas: clinical significance and molecular mechanisms International Forum of Allergy & Rhinology. ,vol. 5, pp. 701- 707 ,(2015) , 10.1002/ALR.21524
Kari Syrjänen, Stina Syrjänen, Detection of human papillomavirus in sinonasal papillomas: Systematic review and meta-analysis The Laryngoscope. ,vol. 123, pp. 181- 192 ,(2013) , 10.1002/LARY.23688
Jeb M. Justice, Kern M. Davis, Daniel A. Saenz, Donald C. Lanza, Evidence that human papillomavirus causes inverted papilloma is sparse. International Forum of Allergy & Rhinology. ,vol. 4, pp. 995- 1001 ,(2014) , 10.1002/ALR.21358
J BECK, K MCCLATCHEY, M LESPERANCE, R ESCLAMADO, T CAREY, C BRADFORD, Presence of human papillomavirus predicts recurrence of inverted papilloma. Otolaryngology-Head and Neck Surgery. ,vol. 113, pp. 49- 55 ,(1995) , 10.1016/S0194-5998(95)70144-3
J BECK, K MCCLATCHEY, M LESPERANCE, R ESCLAMADO, T CAREY, C BRADFORD, Human papillomavirus types important in progression of inverted papilloma Otolaryngology-Head and Neck Surgery. ,vol. 113, pp. 558- 563 ,(1995) , 10.1016/S0194-5998(95)70046-3
Randy Judd, Sherif R. Zaki, Lisa M. Coffield, Bruce L. Evatt, Sinonasal papillomas and human papillomavirus: human papillomavirus 11 detected in fungiform Schneiderian papillomas by in situ hybridization and the polymerase chain reaction. Human Pathology. ,vol. 22, pp. 550- 556 ,(1991) , 10.1016/0046-8177(91)90231-D
Giuseppe Altavilla, Alberto Staffieri, Graziella Busatto, Alessandra Canesso, Luciano Giacomelli, Gino Marioni, Expression of p53, p16INK4A, pRb, p21WAF1/CIP1, p27KIP1, cyclin D1, Ki-67 and HPV DNA in sinonasal endophytic Schneiderian (inverted) papilloma Acta Oto-laryngologica. ,vol. 129, pp. 1242- 1249 ,(2008) , 10.3109/00016480802620647
M HARRIS, J BECK, W LANCASTER, L GREGOIRE, T CAREY, C BRADFORD, The HPV 6 E6/E7 transforming genes are expressed in inverted papilloma Otolaryngology-Head and Neck Surgery. ,vol. 118, pp. 312- 318 ,(1998) , 10.1016/S0194-5998(98)70307-9
David G. Stoddard, Michael G. Keeney, Ge Gao, David I. Smith, Joaquín J. García, Erin K. O’Brien, Transcriptional activity of HPV in inverted papilloma demonstrated by in situ hybridization for E6/E7 mRNA. Otolaryngology-Head and Neck Surgery. ,vol. 152, pp. 752- 758 ,(2014) , 10.1177/0194599815571285
R. L. BRYAN, I. S. BEVAN, J. CROCKER, L. S. YOUNG, Detection of HPV 6 and 11 in tumours of the upper respiratory tract using the polymerase chain reaction. Clinical Otolaryngology. ,vol. 15, pp. 177- 180 ,(1990) , 10.1111/J.1365-2273.1990.TB00453.X