Detection of human papillomavirus in sinonasal papillomas: Systematic review and meta-analysis

摘要: Objectives/Hypothesis: To perform a systematic review and formal meta-analysis of the literature reporting on HPV detection in sinonasal papillomas. Since first reported 1983, etiological role for human papillomavirus (HPV) papillomas has been subject to increasing interest. Study Design: A review, with meta-regression. Methods: Literature was searched through April 2012. The effect size calculated as event rates (95% confidence interval [CI]), homogeneity testing using Cochran's Q I2 statistics. Meta-regression used test impact study-level covariates (HPV method, geographic origin, papilloma type) size, potential publication bias estimated funnel plot symmetry. Results: Seventy-six studies were eligible covering 1,956 from different regions. Altogether, 760 (38.8%) cases tested HPV-positive; 0.421 CI 0.359-0.485, random effects model). summary prevalence highest (65.3%) exophytic (EP), followed by inverted (37.8%) cylindrical cell (22.5%). In stratified 1) technique, 2) study 3) type, between-study heterogeneity significant only types (P = .001). meta-regression, method .102), origin .149), or histological type .240) not covariates. Some evidence found EP. sensitivity analysis, all meta-analytic results robust one-by-one removals. Conclusions: Variability is explained their (not study), but none three meta-regression. Laryngoscope, 2013