Clinical Presentation, Progression, and Outcome of Patients With Clonal B-Cell Counts of Less Than 5 × 109/L, 5 to 10 × 109/L, and More Than 10 × 109/L and Chronic Lymphocytic Leukemia Immunophenotype

摘要: Objectives: The flow cytometric evaluation of peripheral lymphocytosis has led to a dramatic increase in the diagnosis early stage chronic lymphocytic leukemia (CLL) and monoclonal B-cell (MBL). Few studies exist better delineate natural history differences between MBL CLL. Methods: Applying recently updated B-lymphocyte threshold 5 × 109 B lymphocytes/L for CLL, we evaluated initial presentation, disease progression, time treatment (TTT), 10-year overall survival rates patients with less than 10 109/L, more 109/L cells. These clinical/treatment parameters were also compared among MBL, CLL Rai 0, 0 groups. Results: In total, 310 included, 67 5, 75 10, 168 groups. Statistically significant seen when comparing groups regarding anemia ( P = .021 median hemoglobin; .028 <11 g/dL), platelet count .041 count), splenomegaly .013), management plan .012 observation; .0021 chemotherapy), TTT .0033). No statistically difference was survival. Conclusions: Findings suggest that counts behave clinically similar 109/L.