Differential Metabolic Actions of Specific Statins: Clinical and Therapeutic Considerations

摘要: Abstract Significance: Statins, the most widely prescribed drugs in clinical practice, mainly act by reducing plasma level of low-density lipoprotein (LDL)-cholesterol. A shift redox homeostasis to an imbalance between reactive oxygen species generation and endogenous antioxidant mechanisms results oxidative stress that has been implicated pathogenesis various diseases, including those cardiovascular system. Beyond their efficacy lowering LDL cholesterol, statins modulate systems are development atherosclerosis, morbidity, mortality. Recent Advances: Differences specific or dosages result differential metabolic actions arising from off-target unknown action can have important implications for overall patient morbidity Critical Issues: recent meta-analysis a combined analysis suggested high doses increase risk developing type 2 diabetes ...