Grey matter volume differences associated with extremely low levels of cannabis use in adolescence.

摘要: Rates of cannabis use among adolescents are high, and increasing concurrent with changes in the legal status marijuana societal attitudes regarding its use. Recreational is understudied, especially adolescent period when neural maturation may make users particularly vulnerable to effects Δ-9-tetrahydrocannabinol (THC) on brain structure. In current study, we used voxel-based morphometry compare gray matter volume (GMV) forty-six 14-year-old human (males females) just one or two instances carefully matched THC-naive controls. We identified extensive regions bilateral medial temporal lobes as well posterior cingulate, lingual gyri, cerebellum that showed greater GMV users. Analysis longitudinal data confirmed differences were unlikely precede was associated contemporaneous performance Perceptual Reasoning Index future generalized anxiety symptoms The distribution mapped onto biomarkers endogenous cannabinoid system providing insight into possible mechanisms for these effects. SIGNIFICANCE STATEMENT Almost 35% American 10th graders have reported using existing research suggests initiation adolescence long-term neurocognitive understand very little about earliest use, however, because most conducted adults a heavy pattern lifetime This study presents evidence suggesting structural cognitive adolescence. Converging role endocannabinoid timely changing many jurisdictions perceived risk by youth smoking has declined recent years.