Off-line memory consolidation impairments in multiple sclerosis patients receiving high-dose corticosteroid treatment mirror consolidation impairments in depression

摘要: Summary Background Sleep supports the consolidation of procedural memory, however patients with major depression show impaired motor memory performance after a night sleep. It was hypothesized that this impairment is related to hypothalamic–pituitary–adrenal (HPA) axis dysfunction. We tested if high-dose administration corticosteroids impairs off-line in multiple sclerosis (MS). Methods Nine MS receiving corticosteroid therapy (methylprednisolone) and nine alternative (mitoxantrone) were assessed using sequential finger tapping task before polysomnography. In addition, (MD) antidepressants healthy controls assessed. Results Although four groups did not differ practice-dependent learning, subjects mitoxantrone showed markedly overnight-improvements 17% 24% while depressed −9% −10% overnight decrease. without their amount REM sleep, nor MD controls. we find any correlation between sleep consolidation. Conclusion Our results strong intervention into HPA system like comparable impairments seen patients. propose therefore depression-related changes plasma levels rather than per se underlie MD.