BAG3 regulates formation of the SNARE complex and insulin secretion.

摘要: Insulin release in response to glucose stimulation requires exocytosis of insulin-containing granules. Glucose beta cells leads focal adhesion kinase (FAK) phosphorylation, which acts on the Rho family proteins (Rho, Rac and Cdc42) that direct F-actin remodeling. This process docking fusion secretory vesicles sites at plasma membrane is a complex mechanism mediated by SNAREs. transiently disrupts barrier allows redistribution granules more peripheral regions β cell, hence facilitating insulin secretion. In this manuscript, we show for first time BAG3 plays an important role process. We downregulation results increased secretion disruption network. Moreover, binds SNAP-25 syntaxin-1, two components t-SNARE preventing interaction between syntaxin-1. Upon phosphorylated FAK dissociates from allowing formation SNARE complex, destabilization network release.