BAG3-positive pancreatic stellate cells promote migration and invasion of pancreatic ductal adenocarcinoma.
作者： Ye Yuan , Jing‐Yi Jiang , Jia‐Mei Wang , Jia Sun , Chao Li
DOI: 10.1111/JCMM.14352
关键词:
摘要: BAG3 is constitutively expressed in multiple types of cancer cells and its high expression associated with tumour progression poor prognosis PDAC. However, little known about the role regulation stromal microenvironment The current study demonstrated that beside PDAC cells, was also some activated stroma tissue, as well PSCs. In addition, PSCs involved maintenance activation promotion PDACs invasion via releasing cytokines. BAG3-positive promoted IL-8, MCP1, TGF-β2 IGFBP2 a paracrine manner. Furthermore, sustained through IL-6, an autocrine Thereby, provides new insight into involvement remodelling favourable for malignant PDAC, indicating might serve potential target anti-fibrosis
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