Prognostic impact of hepatitis B or C on intrahepatic cholangiocarcinoma.

摘要: BACKGROUND/AIMS Intrahepatic cholangiocarcinoma (ICC) is the second-most common primary liver malignancy, arising from peripheral intrahepatic bile duct epithelium. Hepatitis B virus (HBV) or hepatitis C (HCV) may be involved in development of ICC. We explored prognostic value infection, as well other factors affecting survival patients with METHODS A retrospective chart review was performed for diagnosed ICC between August 2005 and December 2018 at Konkuk University Medical Center. identified a total 131 Overall rates without were determined. Univariate multivariate analyses used to estimate influencing outcomes. RESULTS 17.6% (23/131) positive HBV HCV. significantly younger higher albumin α-fetoprotein than those viral infections. The median hepatitis-positive hepatitis-negative groups 280 213 days, respectively. Survival not different two (p = 0.279). Multivariate indicated that lower serum carbohydrate antigen 19-9 (CA 19-9) < 0.001), T stage 0.042), absence lymph-node metastasis 0.043), receiving curative surgery 0.033) independent predictors better CONCLUSION While influenced number clinical features patients, it did affect rate. Prognostic outcomes CA level, stage, presence lymph node metastasis, surgery.