Highly Selective Sensing Platform Utilizing Graphene Oxide and Multiwalled Carbon Nanotubes for the Sensitive Determination of Tramadol in the Presence of Co‐Formulated Drugs

作者: Mona A. Mohamed , Shimaa A. Atty , Nahla N. Salama , Craig E. Banks

DOI: 10.1002/ELAN.201600668

关键词:

摘要: Novel insights into the strategy of highly precise, carbon-based electrochemical sensors are presented by exploring excellent properties graphene oxide (GO) and multiwalled carbon nanotube composites (GO-MWCNTs/CPE) for sensitive determination tramadol hydrochloride (TRH). Cyclic voltammetry, differential pulse chronoamperometry (CA), impedance spectroscopy (EIS) scanning electron microscopy, X-ray diffraction (XRD) techniques were used to characterize sensor. The linear response obtained TRH using GO-MWCNTs/CPE was found be over range 2.0x10−9 1.1x10−3 M with a good linearity high correlation (0.9996). limits detection quantification 1.50x10−10 4.99 x 10−10 M, respectively. proposed sensor applied in presence co-formulated drugs ketorolac tromethamine (KTM) paracetamol (PAR). shown successfully apply plasma as real samples. Satisfactory recoveries from samples clearly revealed that can clinical analysis, quality control routine pharmaceutical formulations.

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