The effects of hypophysectomy, thyroidectomy, and postoperative infusion of cortisol or adrenocorticotrophin on the structure of the ovine fetal lung.

摘要: We studied the effect of in utero hypophysectomy and replacement therapy with cortisol adrenocorticotropin on maturation lung structure ovine fetuses. Twenty-two festuses underwent at 99-122 days fetal gestation. At term (148-150 days), ten fetuses received an infusion ACTH six cortisol. The remaining were untreated. Morphometric analysis caudal lobe right was performed included measurement minimum interalveolar wall thickness, numerical density Type I II pneumocytes septal tissue, volume tissue air spaces respiratory lung. hypophysectomized animals differed from controls that alveolar walls thicker, less cells greater. Treatment or caused to appear similar lungs control animals. conclude impairs structural can be achieved by a relatively brief term.