Comparative Pharmacology of Nucleoside Transport Inhibitors

摘要: Abstract The few existing nucleoside transport inhibitors are almost equipotent on the transporter in washed human erythrocytes. Large differences exist however tightness of binding and activity presence plasma, as well ex vivo inhibition duration action when given intravenously or orally. Examples presented marked effect adenosine accumulation ischemic myocardium. That may explain remarkable cardioprotection several models a inhibitor with an appropriate pharmacokinetic profile (such R 75 231) is applied.