Expression of vascular permeability factor (vascular endothelial growth factor) and its receptors in breast cancer
作者： Lawrence F Brown , Brygida Berse , Robert W Jackman , Kathi Tognazzi , Anthony J Guidi
DOI: 10.1016/0046-8177(95)90119-1
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摘要: Solid tumors must induce a vascular stroma to grow beyond minimal size, and the intensity of angiogenic response has been correlated with prognosis in breast cancer patients. Vascular permeability factor (VPF), also known as endothelial growth (VEGF), is secreted protein that implicated tumor-associated angiogenesis. directly stimulates cell increases microvascular permeability, leading extravasation plasma proteins, which alter extracellular matrix manner promotes To determine whether VPF role cancer, we used situ hybridization study mRNA expression normal tissue (13 specimens), comedo-type ductal carcinoma (DCIS) (four infiltrating (12 lobular (two metastatic (three specimens) (one specimen). was expressed at low level by duct epithelium but high levels tumor cells all cases DCIS, carcinoma, carcinoma. In contrast, not We two recently described surface receptors, flt-1 kdr. receptor strongly small vessels adjacent malignant no definite labeling for detected or nonmalignant tissue. The intense blood provides strong evidence linking angiogenesis associated ductal,
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