Second primary neoplasms in survivors of Wilms' tumour—A population‐based cohort study from the British Childhood Cancer Survivor Study

摘要: A British population-based cohort study was carried out to determine the risk of second primary neoplasms in survivors Wilms' tumour. The obtained from Childhood Cancer Survivor Study, a treatment toxicities 18,044 individuals diagnosed with childhood cancer, at an age less than 15 years, between 1940 and 1991 Britain. There were 1,441 tumour cohort: 732 males (50.8%) 709 females (49.2%). Total follow-up 5-year survival 27,841 person mean 19.3 years per survivor. 81 neoplasms, including 52 solid 3 acute myeloid leukaemias 26 basal cell carcinomas. Thirty-five 39 that developed thoracic, abdominal or pelvic region occurred within irradiated tissue. standardised incidence ratio for all 6.7 (95% CI: 5.0-8.8). Cumulative by ages 30, 40 50 2.3% (1.4-3.5%), 6.8% (4.6-9.5%) 12.2% (7.3-18.4%). overall treated substantial, tumours tended develop Continued these is important monitor such late effects treatment. It also evaluate following more recent lower radiation dose practices.