Neutrophils Do Not Express IL-17A in the Context of Acute Oropharyngeal Candidiasis

摘要: IL-17 protects against pathogens by acting on nonhematopoietic cells to induce neutrophil recruitment through upregulation of chemokines and G-CSF. IL-17- Th17-deficient humans mice are susceptible mucosal Candida albicans infections, linked impaired responses. production is traditionally associated with CD4+ Th17 cells. However, also expressed during innate responses facilitate rapid pathogen clearance. Innate IL-17-expressing include various lymphocyte-type subsets, including ILC3, NKT, γδ-T "natural" (nTh17) Some reports suggest that neutrophils can express fungal infections. Here, we asked whether serve as a source acute oropharyngeal candidiasis (OPC) using an IL-17A fate-tracking reporter mouse. Mice were subjected OPC for two days, oral tissue was analyzed flow cytometry. TCRβ+ natural cells, recently reported. Although infiltrating recruited the tongue following infection, they did not reporter. Moreover, neutrophil-depleted exhibited normal transcription both Il17a downstream IL-17-dependent gene targets after challenge. Thus, in OPC, measurable production, nor necessary trigger expression, although essential ultimate control.