Basophil responsiveness in chronic urticaria

摘要: Chronic urticaria is a common skin disease without an etiology in the majority of cases. The similarity symptoms and pathology to allergen-induced reactions supports idea that mast cell blood basophil IgE receptor activation involved; however, no exogenous allergen trigger has been identified. Recent evidence role for basophils expression. Specifically, basopenia noted active with recruitment lesional sites. In addition, display altered receptor-mediated degranulation reverts remission. chronic idiopathic (CIU) subjects, changes receptor-signaling molecule expression levels accompany function basophils. arrival therapies targeting further shown behavior potential use as biomarker CIU.