Selective function of PKC-theta in T cells.

摘要: T cell activation is a critical process in initiating adaptive immune response since only through this the naive antigen specific cells differentiate into armed effector that mediate actual response. During activation, undergo clonal expansion and acquire capability to kill target infected with pathogens or produce cytokines essential for regulating Inappropriate inactivation of leads autoimmunity severe immunodeficiencies. PKC-theta selectively expressed required mediating process. Mice deficient exhibit defects survival activation-induced death. translocates immunological synapse mediates signals NF-kappaB, AP1 NFAT are activation. Furthermore, PKC-theta-/- mice displayed multiple development cell-mediated responses vivo. thus molecule regulates function at stages