Inverted latency specific binding assay

摘要: A specific binding assay composition and method for determining a ligand in sample are disclosed. The comprises (a) partner the ligand; (b) detection system which has at least two components; (c) selectively accessible vesicle having surface-incorporated or analog first component of therein; (d) substance modifies accessibility response to surface-associated partner; (e) one additional is reactive with produce detectable reduced by association modifying variabily vesicle. decrease signal measured upon reaction as compared unreacted vesicles.