Convergence of genetic findings for nicotine dependence and smoking related diseases with chromosome 15q24-25.
DOI: 10.1016/J.TIPS.2009.10.004
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摘要: Due to the adverse health consequences related smoking, it is important understand factors that contribute nicotine dependence. The most replicated genetic finding for dependence points variants on chromosome 15, which includes α5-α3-β4 nicotinic receptor gene cluster. A compelling functional variant a polymorphism, rs16969968, alters an amino acid in α5 subunit. Several prominent studies report locus also influences risk lung cancer and chronic obstructive pulmonary disease. This represents exciting convergence of findings, highlights potential research smoking inform public health.
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