Morphological changes in spleen after dietary zinc deficiency and supplementation in Wistar rats

摘要: Abstract Background Study was conducted to determine the effect of dietary zinc deficiency and supplementation on spleen morphology. Methods Pre-pubertal Wistar rats (40–50 g) were divided into two groups with 6 sub-groups each viz. control (ZC, 100 μg/g diet), pair fed (PF, deficient (ZD, Results In present study body weight BMI decreased significantly along incidence splenomegaly as typified by increased splenic index in compared that respective groups. Histopathological changes such disorganization red pulp, several infiltered lymphocytes, vacuolization, loss cellularity, karyolysis, dissolution matrix, indistinct differentiation between white pulp evident 2ZD 4ZD group animals. Degeneration more severe after 4 weeks giant cells formation hypertrophy also evident. Conclusion The findings revealed causes growth retardation splenomegaly. Degenerative atrophic rat suggest reduced cellular defense potential which will have a direct immunity. Zinc may prove be beneficial there varying degrees recovery cessation deficiency.