N-Acetylcysteine as Modulator of the Essential Trace Elements Copper and Zinc.
作者： Theresa Wolfram , Maria Schwarz , Michaela Reuß , Kristina Lossow , Mario Ost
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摘要: N-acetylcysteine (NAC) is a frequently prescribed drug and known for its metal chelating capability. However, to date it not well characterized whether NAC intake affects the homeostasis of essential trace elements. As precursor glutathione (GSH), also has potential modulate cellular redox homeostasis. Thus, we aimed analyze effects acute chronic treatment on copper (Cu) zinc (Zn) activity redox-sensitive transcription factor Nrf2. Cells were exposed 1 mM co-treated with 50 μM Cu or Zn. We showed that reduced concentration Zn Cu. In addition, inhibited Zn-induced Nrf2 activation limited concomitant upregulation GSH concentrations. contrast, mice chronically received via drinking water (1 g NAC/100 mL). concentrations decreased in liver spleen. duodenum, NQO1, TXNRD, SOD activities upregulated by NAC. All them can be induced Nrf2, thus indicating putative activation. Overall, modulates both vitro vivo accordingly balance.
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