Epstein-Barr Virus-Associated Gastric Carcinoma: Use of Host Cell Machineries and Somatic Gene Mutations
作者： Hiroyuki Abe , Atsushi Kaneda , Masashi Fukayama
DOI: 10.1159/000434683
关键词:
摘要: Epstein-Barr virus (EBV)-associated gastric carcinoma (EBVaGC) is a distinct subtype of carcinoma, consisting clonal growth EBV-infected epithelial cells. Its unique characteristics have been demonstrated by epidemiological, clinical and pathological studies using in situ hybridization for EBV-encoded small RNAs. An oncogenic process EBVaGC has also revealed. EBV uses various host-cell machineries, including cell division machinery to propagate genomes, DNA-methylation epigenetically control infected cells, microRNA exosome machineries modify the behavior microenvironment Recent comprehensive molecular analyses from The Cancer Genome Atlas project demonstrate that representative microsatellite unstable, genomically stable chromosome unstable subtypes. In addition having highest level DNA methylation CpG islands promoter regions, harbors particular gene alterations, high frequency mutations PIK3CA ARID1A, mutation BCOR, amplification PD-L1 PD-L2. Although currently undetermined, might use altered cellular functions are induced these somatic mutations. Further investigation virus-driven oncogenesis will enable hitherto unknown stomach be elucidated, which may reveal potential therapeutic targets EBVaGC.
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