Microbicidal cationic proteins in rabbit alveolar macrophages: a potential host defense mechanism.

摘要: Rabbit alveolar macrophages contain two highly cationic microbicidal proteins. These were shown to be distinct from histones and not arise granulocyte contamination. The macrophage proteins especially active against Candida albicans parapsilosis. Gram-positive bacteria (Bacillus subtilis, Listeria monocytogenes, Streptococcus faecalis) also susceptible, whereas Escherichia coli Salmonella typhimurium appeared more resistant. may present in lysosomes, based on their solubilization by dilute acids distribution with lysosomal markers sucrose density gradients. Such have previously been demonstrated any mammalian macrophage. They play a significant role the host-defense functions of rabbit lung.