Evidence of reporting biases in voxel-based morphometry (VBM) studies of psychiatric and neurological disorders

摘要: Objectives To evaluate whether biases may influence the findings of whole-brain structural imaging literature. Methods Forty-seven voxel-based meta-analyses including morphometry (VBM) studies in neuropsychiatric conditions were included, for a total 324 individual VBM studies. The sample size, overall number foci, and different moderators extracted both at level meta-analyses. Results Sample size ranged from 12 to 545 (median n = 47) per study. median reported foci study was six. with larger sizes only slightly more abnormalities than smaller (2% increase 10-patients size). A similar pattern seen several analyses according moderator variables some possible modulating evidence statistical threshold employed, publication year coauthors. Whole-brain n = 534) found fewer (median = 3) single they showed no significant increasing size. Meta-analyses ≥10 three while there relationship between (median = 5) <10 studies. Conclusions The small even few often be inflated. This picture is consistent reporting affecting Hum Brain Mapp 35:3052–3065, 2014. © 2013 Wiley Periodicals, Inc.