Lack of Evidence for Regional Brain Volume or Cortical Thickness Abnormalities in Youths at Clinical High Risk for Psychosis: Findings From the Longitudinal Youth at Risk Study

摘要: There is cumulative evidence that young people in an "at-risk mental state" (ARMS) for psychosis show structural brain abnormalities frontolimbic areas, comparable to, but less extensive than those reported established schizophrenia. However, most available data come from ARMS samples Australia, Europe, and North America while large studies other populations are missing. We conducted a magnetic resonance imaging study relatively sample of 69 individuals 32 matched healthy controls (HC) recruited Singapore as part the Longitudinal Youth At-Risk Study (LYRIKS). used 2 complementary approaches: voxel-based morphometry surface-based analysis to extract regional gray white matter volumes (GMV WMV) cortical thickness (CT). At whole-brain level, we did not find any statistically significant difference between HC groups concerning total GMV WMV or GMV, WMV, CT. The additional comparison regions interest, hippocampal, ventricular volumes, return either. Several characteristics LYRIKS like Asian origins absence current illicit drug use could explain, alone conjunction, negative findings suggest there may be no dramatic volumetric CT ARMS.