Polyisoprenoid alcohols—Recent results of structural studies

摘要: Polyisoprenoid alcohols (polyprenols and dolichols) are linear polymers of from several up to more than 100 isoprene units identified in almost all living organisms. Studies their chemical structures have resulted the discovery new variants such as recently described alloprenols with reversed configuration double bond alpha-isoprene unit. In parallel, structural elucidation metabolically labeled plant dolichols has indicated that both mevalonate methylerythritol phosphate pathways involved biosynthesis roots, leading construction a spatial model biosynthesis. According this model, root cells, synthesis dolichol molecule is initiated plastids, resulting intermediates, oligoprenyl diphosphates, exported cytoplasm elongated desired chain length. The metabolic consequences putative discussed context enzymatic machinery involved.