Virus-associated immunopathology: animal models and implications for human disease. 1. Effects of viruses on the immune system, immune-complex diseases, and antibody-mediated immunologic injury.

摘要: The tissue damage caused by virus infection has been traditionally explained the ability of viruses to multiply in cells and thereby injure or destroy them. Recent evidence suggests, however, that lesions may also be host's immune response viral antigens system itself perturbed some viruses. This memorandum reviews recent developments immunopathology, with special reference animal model systems, indicates possible relevance new concepts techniques for certain diseases man. Certain viruses, notably leukaemia those causing persistent infections, depress mount an antibody antigens, while other enhance response. Cell-mediated immunity depressed. Another immunopathological manifestation is immune-complex disease. When their persist circulation they combine specific antibody, resulting complexes lodge various sites, especially kidney. Further combination complement leads release tissue-damaging substances. A third condition associated antibody-mediated immunologic injury. Both oncogenic non-oncogenic frequently induce on surface invade. attaches these presence complement, are destroyed.