Regional Differences in Rat Vaginal Smooth Muscle Contractility and Morphology
作者： Laura C. Skoczylas , Zegbeh Jallah , Yoshio Sugino , Suzan E. Stein , Andrew Feola
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摘要: The objective of this study was to define the regional differences in rat vaginal smooth muscle contractility and morphology. We evaluated circumferential segments from proximal, middle, distal vagina (n = 21) vitro. Contractile responses carbachol, phenylephrine, potassium chloride, electrical field stimulation (EFS) were measured. Immunohistochemical analyses also performed. dose–response curves for carbachol- phenylephrine-dependent contractions different (P .05, P .04) compared proximal/middle regions. Adjusted region-dependent changes contractility, generated lower force response carbachol higher phenylephrine. There less with increasing EFS frequency .03), Cholinergic versus adrenergic nerves more frequent proximal region .03). In summary, results indicate that functional morphological nerve fibers regions exist.
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