Contrasting effects of E type prostaglandin (EP) receptor agonists on core body temperature in rats
作者： Takakazu Oka , Kae Oka , Clifford B. Saper
DOI: 10.1016/S0006-8993(03)02268-6
关键词:
摘要: Prostaglandin E2 (PGE2) is thought to be a principal fever mediator. There are four subtypes of PGE (EP) receptors, EP1-EP4. We investigated which EP receptors mediate PGE2-induced hyperthermia by injecting selective receptor agonists into the rat lateral cerebral ventricle under unrestrained condition. ONO-DI-004, an EP1 agonist, increased core temperature (T(c)) in dose-dependent manner (1.6+/-0.1 degrees C at 20 nmol, with peak 30 min after injection) time course similar hyperthermia. ONO-AE1-259-01 (20 nmol), EP2 did not change T(c). ONO-AE-248 EP3 also However, effect was delayed (1.2+/-0.2 C, 50 compared PGE2. In contrast, ONO-AE1-329, EP4 decreased These findings suggest that EP1, EP3, and all may contribute thermoregulatory response PGE2, but each have different role.
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sci-hub.se 参考文章(32)
Florence Rage, Byung Ju Lee, Ying J. Ma, Sergio R. Ojeda, Estradiol enhances prostaglandin E2 receptor gene expression in luteinizing hormone-releasing hormone (LHRH) neurons and facilitates the LHRH response to PGE2 by activating a glia-to-neuron signaling pathway. The Journal of Neuroscience. ,vol. 17, pp. 9145- 9156 ,(1997) , 10.1523/JNEUROSCI.17-23-09145.1997
Philip A. Mackowiak, Fever : basic mechanisms and management Raven Press. ,(1991)
Fumitaka Ushikubi, Eri Segi, Yukihiko Sugimoto, Takahiko Murata, Toshiyuki Matsuoka, Takuya Kobayashi, Hiroko Hizaki, Kazuhito Tuboi, Masato Katsuyama, Atsushi Ichikawa, Takashi Tanaka, Nobuaki Yoshida, Shuh Narumiya, Impaired febrile response in mice lacking the prostaglandin E receptor subtype EP3. Nature. ,vol. 395, pp. 281- 284 ,(1998) , 10.1038/26233
Yves Boie, Rino Stocco, Nicole Sawyer, Deborah M Slipetz, Mark D Ungrin, Frank Neuschäfer-Rube, Gerhard P Püschel, Kathleen M Metters, Mark Abramovitz, Molecular cloning and characterization of the four rat prostaglandin E2 prostanoid receptor subtypes European Journal of Pharmacology. ,vol. 340, pp. 227- 241 ,(1997) , 10.1016/S0014-2999(97)01383-6
Kae Oka, Takakazu Oka, Tetsuro Hori, Prostaglandin E2 may induce hyperthermia through EP1 receptor in the anterior wall of the third ventricle and neighboring preoptic regions Brain Research. ,vol. 767, pp. 92- 99 ,(1997) , 10.1016/S0006-8993(97)00562-3
J T Stitt, Differential sensitivity in the sites of fever production by prostaglandin E1 within the hypothalamus of the rat. The Journal of Physiology. ,vol. 432, pp. 99- 110 ,(1991) , 10.1113/JPHYSIOL.1991.SP018378
Masako Hosoi, Takakazu Oka, Tetsuro Hori, Prostaglandin E receptor EP3 subtype is involved in thermal hyperalgesia through its actions in the preoptic hypothalamus and the diagonal band of Broca in rats. Pain. ,vol. 71, pp. 303- 311 ,(1997) , 10.1016/S0304-3959(97)03380-0
Monica Ek, Carlos Arias, Paul Sawchenko, Anders Ericsson-Dahlstrand, Distribution of the EP3 prostaglandin E2 receptor subtype in the rat brain: Relationship to sites of interleukin‐1–induced cellular responsiveness The Journal of Comparative Neurology. ,vol. 428, pp. 5- 20 ,(2000) , 10.1002/1096-9861(20001204)428:1<5::AID-CNE2>3.0.CO;2-M
Takakazu Oka, Tetsuro Hori, Masako Hosoi, Kae Oka, Michie Abe, Chiharu Kubo, Biphasic modulation in the trigeminal nociceptive neuronal responses by the intracerebroventricular prostaglandin E2 may be mediated through different EP receptors subtypes in rats Brain Research. ,vol. 771, pp. 278- 284 ,(1997) , 10.1016/S0006-8993(97)00802-0
Takakazu Oka, Masako Hosoi, Kae Oka, Tetsuro Hori, Biphasic alteration in the trigeminal nociceptive neuronal responses after intracerebroventricular injection of prostaglandin E2 in rats. Brain Research. ,vol. 749, pp. 354- 357 ,(1997) , 10.1016/S0006-8993(96)01421-7