Biphasic alteration in the trigeminal nociceptive neuronal responses after intracerebroventricular injection of prostaglandin E2 in rats.
作者： Takakazu Oka , Masako Hosoi , Kae Oka , Tetsuro Hori
DOI: 10.1016/S0006-8993(96)01421-7
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摘要: Abstract To investigate the role of prostaglandin E2 (PGE2) in brain nociception electrophysiologically, we injected PGE2 (0.1 fmol-1 nmol) into lateral cerebroventricle (LCV) anesthetized rats and observed changes responses wide dynamic range (WDR) neurons trigeminal nucleus caudalis to noxious pinching facial skin. The LCV injection at 1 fmol 10 enhanced majority WDR stimuli, whereas that 100 pmol nmol suppressed them. enhancement suppression nociceptive were 15–25 min 5–15 min after 10 fmol (3.53 pg) (353 ng), respectively. On other hand, both had no effect on low threshold mechanoreceptive skin brushing. These results provide electrophysiological evidence brain-derived has biphasic effects nociception, i.e., it induces mechanical hyperalgesia lower doses hypoalgesia higher rats.
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