Effects of inhaled corticosteroids in stable chronic obstructive pulmonary disease.

摘要: Chronic obstructive pulmonary disease (COPD) has been described as a heterogeneous multifactorial disorder associated with an abnormal inflammatory response of the peripheral airways and variable morphologic, physiologic clinical phenotypes. This notion is actually poorly supported by data, there are substantial discrepancies weak correlation between inflammation, structural damage, functional impairment degree symptoms. problem compounded poor understanding complexity intricacies on pathways in COPD. Despite evidence for efficacy inhaled corticosteroids (ICS) selected endpoints COPD, we cannot assume that anti-inflammatory treatment ICS alone or combination long-acting bronchodilators will necessarily improve underlying processes patient relevant outcomes Given widespread use COPD across all severities, it important to weigh their clinically proven benefits shortcomings cautiously critically. Reviewed current evidence-based role markers