Tumor marker protein and antibodies thereto for cancer risk assessment or diagnosis
作者： Margaret Hanausek-Walaszek , Zbigniew Walaszek , Thomas J. Slaga
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摘要: A tumor-associated marker protein was purified and antibodies thereto developed for cancer diagnosis assessment of risk associated with the long-term use synthetic steroid hormones, both contraceptive non-contraceptive, other drugs that exhibit tumor promotional properties. The provided are interspecies immunologically cross-reactive. In summary, p65 factor present invention has following characteristics: (a) binds substantially completely to a phenyl hydrophobic interaction column in buffer containing 20% ammonium sulfate eluted at ca. 16% sulfate; (b) localized primarily nuclear envelopes only small amounts cytoplasm from where is released blood circulation vivo or cell culture medium vitro; (c) induced normal, adult tissues by chemical carcinogens (initiators) but not promoters, carcinogen-induced production being enhanced latter. Also disclosed herein processes purifying 65 kDa plasma, cytosol ascitic fluid carcinoma bearing animals; producing antisera antibody preparations marker; methods using diagnose assess likelihood cancer.
lens.org 参考文章(12)
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