Prenatal administration of lipopolysaccharide induces sex-dependent changes in glutamic acid decarboxylase and parvalbumin in the adult rat brain.

摘要: Abstract Rationale Recent clinical studies suggest GABA-ergic system abnormalities as a neuropathological mechanism of schizophrenia. Objectives In the present study, we examined effect chronic prenatal lipopolysaccharide (LPS) administration on immunohistochemical changes glutamate decarboxylase (GAD67) and parvalbumin (PV)-expressing neurons in medial prefrontal cortex hippocampus rats. Results These data demonstrated that LPS during final 2 weeks pregnancy induced schizophrenia-like behavioral symptoms, such deficits sensorimotor gating (prepulse inhibition) impairments social interactions exploration, adult offspring. Moreover, analysis revealed our neurodevelopmental model schizophrenia, decreases total number PV- GAD67-positive cortices females prenatally exposed to were observed, whereas these immunochemical primarily detected males. Additionally, decrease PV-labeled axon terminals cells, likely reflecting perisomatic inhibitory innervation pyramidal neurons, was observed both sexes. Conclusion This study provided evidence key role for GABA neurodevelopment associated with etiopathogenesis schizophrenia showed are sex-dependent. this is first based administration, which not only produced but also changed cytoarchitecture system.