Farklı immünsüpresan ajanların gingival büyüme üzerine olan etkisinin değerlendirilmesi
作者： Ahu Adali
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摘要: Bu calismanin amaci, immunsupresan olarak kullanilan Tac ve CsA'nin disetibuyumesi uzerindeki etkilerinin degerlendirilmesidir.Calismaya, 60 CsA kullanan 40 birey dahil edildi. Tumhastalarin alt ust anterior dislerinden plak indeksi, gingival indeks, papillerkanama cep derinligi diseti buyumesi indeksi degerleri kaydedildi.Ayrica, immunosupresanlarin gunluk ilac dozu, kan Tac/CsAduzeyi, kalsiyum kanal blokoru kullanimi gibi farmakolojik degiskenler dekaydedildi. 9 10 hastanin, renal transplant oncesi 3-6ay sonrasinda kaydedildi; tedavi takip sonrasi buyumesidegerlendirildi.CsA hastalarin 10'unda klinik anlamli buyumesisaptanirken, hicbir bireyde buyumesitespit edilmedi. Iki grup arasinda periodontal parametreler (PI,GI,PKI,CD),yas, transplanttan sonra gecen sure acisindan da fark saptandi; klinikolarak dagilimi, agiz solunumu aliskanligi dagilimiacisindan saptandi. grubunda, gozlenen/gozlenmeyen bireyler arasinda, parametreler(PI,GI,PKI,CD), yuzdesi glukokortikoid dozuacisindan iliski goruldu; hasta grubunda kalsiyumkanal kullanan/kullanmayan gruplar buyumesiyuzdesi belirlendi. Tedavi takibi yapilan grupta, buyumesikaydedilmedi.Sonuc olarak, kullaniminin, benzer etki mekanizmasina sahip CsA'ninaksine, buyumesine neden olmadigi tespit edilmistir. Immunosupresanajanin degistirilmesinde sakinca durumlarda, buyumesigozlenen hastalarda, Tac'in iyi bir secenek oldugunu dusunmekteyiz. Ayrica,3-6 aylik gozlem sonucunda, tedavi, oral hijyeninsaglanmasinin, buyumesini azaltabilecegini soyleyebiliriz. AbstractThe purpose of this study is to evaluate the effect differentimmunosuppressant agents on overgrowth.60 patients medicated with and wererecruited in study. Periodontal examination (plaque index, index,papillary bleeding pocket depth GO index) was carried out only formaxillary mandibular teeth. Pharmacologic variables such asdaily dosage immunosuppressant agents, Tac/CsA whole blood level andcalcium channel blocker usage were also recorded. 19 (9 patientsmedicated Tac) evaluatedbefore transplantation procedure, received hygiene instructions,periodontal treatment, maintenance therapy, monitored for3-6 months out.In group CsA, had clinically significant GOwhilst none GO.Significant differences observed for parameters(PI,GI,PBI,PD), age, posttransplant period, % GO, GOdistribution mouthbreathing behaviour between two groups. In CsAgroup, difference detected parameters, ofGO daily glococorticoid responders nonresponders.% showed statistically betweenpaitents either calcium blockers or not group.No treatment group.The results from our show that doesn?t occur medicatedwith Tac, although shares same mechanism CsA. We think ogood choice suffering if a change about drug regimen isconsidered. Besides, we can conclude periodontalmaintenance therapy good minimise end of3-6 monitoring period.
参考文章(150)
J. F. Borel, Camille Feurer, H. U. Gubler, H. Stähelin, Biological effects of cyclosporin A: A new antilymphocytic agent Inflammation Research. ,vol. 6, pp. 179- 186 ,(1976) , 10.1007/BF01973261
R. A. Seymour, P. A. Heasman, Drugs and the periodontium Journal of Clinical Periodontology. ,vol. 15, pp. 1- 16 ,(1988) , 10.1111/J.1600-051X.1988.TB01549.X
A. S. Narayanan, D. F. Meyers, R. C. Page, Regulation of collagen production in fibroblasts cultured from normal and phenytoin-induced hyperplastic human gingiva. Journal of Periodontal Research. ,vol. 23, pp. 118- 121 ,(1988) , 10.1111/J.1600-0765.1988.TB01343.X
S Busque, P Demers, G St-Louis, J.-G Boily, J Tousignant, F Lemieux, C Smeesters, J Corman, P Daloze, Conversion from Neoral (cyclosporine) to tacrolimus of kidney transplant recipients for gingival hyperplasia or hypertrichosis. The International Congress on Immunosuppression. ,vol. 30, pp. 1247- 1248 ,(1998) , 10.1016/S0041-1345(98)00229-2
J. Naranjo, J. Poniachik, D. Cisco, J. Contreras, D. Oksenberg, J.M. Valera, J.C. Díaz, J. Rojas, G. Cardemil, S. Mena, J. Castillo, G. Rencoret, J. Godoy, J. Escobar, J. Rodríguez, P. Leyton, A. Fica, C. Toledo, Oral ulcers produced by mycophenolate mofetil in two liver transplant patients. Congress of the Chilean Transplantation Society. ,vol. 39, pp. 612- 614 ,(2007) , 10.1016/J.TRANSPROCEED.2006.12.028
Mario Aimetti, Federica Romano, Cesare Debernardi, Effectiveness of periodontal therapy on the severity of cyclosporin A-induced gingival overgrowth. Journal of Clinical Periodontology. ,vol. 32, pp. 846- 850 ,(2005) , 10.1111/J.1600-051X.2005.00774.X
Edward J. Zebrowski, Susan P. Pylypas, Olva Odlum, Roger B. Johnson, Comparative Metabolism of 3H-Glucosamine by Fibroblast Populations Exposed to Cyclosporine Journal of Periodontology. ,vol. 65, pp. 565- 567 ,(1994) , 10.1902/JOP.1994.65.6.565
J. M. Thomason, J. S. Ellis, P. J. Kelly, R. A. Seymour, Nifedipine pharmacological variables as risk factors for gingival overgrowth in organ-transplant patients. Clinical Oral Investigations. ,vol. 1, pp. 35- 39 ,(1997) , 10.1007/S007840050006
R. A. Seymour, D. G. Smith, S. R. Rogers, The comparative effects of azathioprine and cyclosporin on some gingival health parameters of renal transplant patients. A longitudinal study. Journal of Clinical Periodontology. ,vol. 14, pp. 610- 613 ,(1987) , 10.1111/J.1600-051X.1987.TB01524.X
Jeong-Won Paik, Chang-Sung Kim, Kyoo-Sung Cho, Jung-Kiu Chai, Chong-Kwan Kim, Seong-Ho Choi, Inhibition of cyclosporin A-induced gingival overgrowth by azithromycin through phagocytosis: an in vivo and in vitro study. Journal of Periodontology. ,vol. 75, pp. 380- 387 ,(2004) , 10.1902/JOP.2004.75.3.380