Nubp1 Is Required for Lung Branching Morphogenesis and Distal Progenitor Cell Survival in Mice
作者： Carsten Schnatwinkel , Lee Niswander
DOI: 10.1371/JOURNAL.PONE.0044871
关键词:
摘要: The lung is a complex system in biology and medicine alike. Whereas there good understanding of the anatomy histology embryonic adult lung, less known about molecular details cellular pathways that ultimately orchestrate formation affect its health. From forward genetic approach to identify novel genes involved formation, we identified mutated Nubp1 gene, which leads syndactyly, eye cataract hypoplasia. In expressed progenitor cells distal epithelium. Nubp1(m1Nisw) mutants show increased apoptosis accompanied by loss markers Sftpc, Sox9 Foxp2. addition, mutation disrupts localization polarity protein Par3 mitosis relevant Numb. Using knock-down studies epithelial cells, also demonstrate function regulating centrosome dynamics microtubule organization. Together, represents an essential for survival coordinating vital processes including cell centrosomal dynamics.
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W M Thurlbeck, Measurement of pulmonary emphysema. The American review of respiratory disease. ,vol. 95, pp. 752- 764 ,(1967) , 10.1164/ARRD.1967.95.5.752
Greg Holmes, Lee Niswander, Expression of slit‐2 and slit‐3 during chick development Developmental Dynamics. ,vol. 222, pp. 301- 307 ,(2001) , 10.1002/DVDY.1182
Maria Barna, Nicola Hawe, Lee Niswander, Pier Paolo Pandolfi, Plzf regulates limb and axial skeletal patterning Nature Genetics. ,vol. 25, pp. 166- 172 ,(2000) , 10.1038/76014
K.H. Kaestner, E. Grau, G. Schutz, A.P. Monaghan, Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm Development. ,vol. 119, pp. 567- 578 ,(1993) , 10.1242/DEV.119.3.567
Jürgen A. Knoblich, Jan, Yuh Nung Jan, Asymmetric segregation of Numb and Prospero during cell division Nature. ,vol. 377, pp. 624- 627 ,(1995) , 10.1038/377624A0
M. J. Garcia-Garcia, J. T. Eggenschwiler, T. Caspary, H. L. Alcorn, M. R. Wyler, D. Huangfu, A. S. Rakeman, J. D. Lee, E. H. Feinberg, J. R. Timmer, K. V. Anderson, Analysis of mouse embryonic patterning and morphogenesis by forward genetics Proceedings of the National Academy of Sciences of the United States of America. ,vol. 102, pp. 5913- 5919 ,(2005) , 10.1073/PNAS.0501071102
Ahmed HK El-Hashash, Gianluca Turcatel, Denise Al Alam, Sue Buckley, Hiroshi Tokumitsu, Saverio Bellusci, David Warburton, Eya1 controls cell polarity, spindle orientation, cell fate and Notch signaling in distal embryonic lung epithelium Development. ,vol. 138, pp. 1395- 1407 ,(2011) , 10.1242/DEV.058479
E. L. Rawlins, L. E. Ostrowski, S. H. Randell, B. L. M. Hogan, Lung development and repair: Contribution of the ciliated lineage Proceedings of the National Academy of Sciences of the United States of America. ,vol. 104, pp. 410- 417 ,(2007) , 10.1073/PNAS.0610770104
Ian G Macara, Par proteins: partners in polarization. Current Biology. ,vol. 14, pp. 160- 162 ,(2004) , 10.1016/J.CUB.2004.01.048
J. Que, X. Luo, R. J. Schwartz, B. L. M. Hogan, Multiple roles for Sox2 in the developing and adult mouse trachea Development. ,vol. 136, pp. 1899- 1907 ,(2009) , 10.1242/DEV.034629