Thoracic (Lung/Thymus) Neuroendocrine Neoplasms

摘要: Thoracic neuroendocrine neoplasms include pulmonary and thymic tumors. Well-differentiated tumors are currently classified as typical atypical carcinoids based on mitotic index presence of necrosis. Large cell carcinoma (LCNEC) accounts for 3% or less all lung cancers, but its prevalence is destined to increase due heightened diagnostic awareness increased use immunohistochemistry refining poorly differentiated Small (SCLC) about 15% carcinomas worldwide most arising in the lung. Neuroendocrine thymus account 2–5% The pathological features alterations nonneoplastic preinvasive conditions encompass a spectrum morphological changes ranging from linear hyperplasia tumorlets. role these lesions precursors postulated well tumors, mainly those peripheral location that may be associated with up 75% cases. By contrast, probably not development high-grade small large whose origin seems more complex possibly linked also other types (including type II alveolar cells).